Published December 29, 1990
by Oxford University Press, USA .
Written in English
|The Physical Object|
|Number of Pages||248|
The book, 'Receptor-Effector Coupling, which has recently appeared in the 'Practical Approach' series from IRL Press and has been edited by E,C, Huime, will be welcomed by both basic research scientists and people interested in using biological. Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume ) Abstract Platelet aggregation and degranulation are complex cellular responses initiated by interaction of physiological stimuli with specific plasma membrane hisn-alarum.com by: 4. About this book R. A. J. Challiss assembles in Receptor Signal Transduction Protocols an outstanding collection of state-of-the-art methods from leading experts for interrogating ligand-receptor and receptor-effector interactions. The action of receptors to catalyze rather than regulate by allostery the activation of G proteins by GTP is emphasized, as is the role of subunit dissociation, without which receptors could not act as catalysts. Current views of intramembrane networking of G protein-mediated receptor-effector coupling Cited by:
Designed to be easily reproducible, the protocols offered include chimeric receptor construction, antibody generation, transient and stable transfection methods, in situ hybridization, as well as immunocytochemistry, functional assays of G-protein function, antisense methods for defining receptor-effector coupling pathways, and many more. The individual chapters provide detailed experimental protocols covering various topics, from the effects of ligand binding on receptor conformation and effector coupling, to moving inside the cell in order to capture the spatial and temporal characteristics of signaling events. Many different mammalian cell-surface receptors are coupled to a trimeric signal-transducing G protein. As noted earlier, ligand binding to these receptors activates their associated G protein, which then activates an effector enzyme to generate an intracellular second messenger (see Figure a). All G protein – coupled receptors (GPCRs) contain seven membrane-spanning regions with their N Cited by: 2. Jun 01, · Search for this keyword. Advanced Search. Main menuAuthor: Shailesh Banerjee.
Receptor-effector coupling: a practical approach. Summary: One of three volumes covering practical aspects of neurotransmitter and hormone-receptor-ligand interactions, receptor biochemistry, and receptor-effector coupling. the cellular response (also called receptor-effector coupling). Among the most important ones are the following: (1) direct control of ion channels in the cell membrane, (2) regulation of cellular activity by way of intracellular chemical signals, such as cyclic adenosine 3′,5′-monophosphate (cAMP), inositol phosphates, or calcium ions. Ligand comes in to change the shape of receptor, to activate _ Note- effectors can cause enzyme activation, ion mobilization -A protein macromolecule which is directly linked to inter- an Note- Lock can fit multiple keys, but only certain ones can un Binding Domains of Ligand Gated Ion Cha REFRACTORY PERIOD FOR LIGAND GATED. Jan 29, · Endothelial Modulation of Cardiac Function book. Endothelial Modulation of Cardiac Function. DOI link for Endothelial Modulation of Cardiac Function. Endothelin Receptor-Effector Coupling and Signaling in Cardiac Cells. With Laurence L. Brunton. View abstract. chapter 10 | 17 pages Endothelin and Cardiac Hypertrophy. With Hiroshi hisn-alarum.com Edition: 1st Edition.